A lysosome-targeted dextran-doxorubicin nanodrug overcomes doxorubicin-induced chemoresistance of myeloid leukemia

Abstract The hypoxic microenvironment is presumed to be a sanctuary for myeloid leukemia cells that causes fp9550bk relapse following chemotherapy, but the underlying mechanism remains elusive.Using a zebrafish xenograft model, we observed that the hypoxic hematopoietic tissue preserved most of the chemoresistant leukemic cells following the doxoru

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